Zyvox tablets 600 mg for bacterial infections (antibiotic, linezolid)

What are Zyvox 600 mg tablets for bacterial infections (antibiotic, linezolid)?

Zyvox tablets contain linezolid, a synthetic antibiotic belonging to the oxazolidinone family. Linezolid functions by inhibiting the initiation of protein synthesis in bacteria. It boasts an exceptional oral bioavailability rate of 100%, owing to its rapid and complete absorption upon oral administration. Notably, Zyvox tablets exhibit comparable efficacy to intravenous injections.

These tablets are valuable in combating bacterial infections caused by Gram-positive bacteria, which have developed resistance to all other antibiotics. Zyvox tablets are particularly useful in treating conditions such as vancomycin-resistant Enterococcus faecium infections, pneumonia, skin and soft tissue infections, as well as sepsis resulting from methicillin-resistant Staphylococcus aureus.

It is important to exercise caution when using this potent antibiotic and reserve it for infections that are not easily treatable with broad-spectrum antibiotics.

Active principles: linezolid

Amount: 10 tablets

Maker: Pfizer Pharmaceutical Inc., Tokyo, Japan

Indications: treatment of infections caused by vancomycin-resistant Enterococcus faecium (VRE), and pneumonia, skin infections and sepsis caused by methicillin-resistant Staphylococcus aureus (MRSA).

How to take

For adults and children aged 12 years or over: take 1 tablet (600 mg of the active principle) at a time, 2 times a day, every 12 hours.

For children under 12 years of age: take 10 mg/kg of the active principle at a time, every 8 hours. However, each dose should not exceed 600 mg. 

This medicine contains 600 mg of the active principle in 1 tablet.

Contraindications: do not use for the following patients:

• patients with myelosuppression such as anemia, renal dysfunction or liver dysfunction,
• patients with body weight less than 40 kg,
• patients on hemodialysis,
• pregnant or breastfeeding women. 

Important information

Patient should undergo regular blood test (approximately once a week) to avoid the occurrence of myelosuppression or hyponatremia.

If you have repeatedly occurring nausea or vomiting, contact your doctor immediately to avoid the occurrence of acidosis. 

In rare cases, pseudomembranous colitis may occur. If you experience abdominal pain or frequent diarrhea while taking this medicine or in 2-3 weeks finishing the treatment, contact your doctor immediately.

If you take this medicine for longer than 28 days and notice unusual eye symptoms such as decline in visual acuity, color blindness, blurred vision or visual field defect (defect in the visual field), contact your doctor immediately avoid the occurrence of optic nerve disorder may occur and further progress to vision loss.

Avoid taking excessive amounts of tyramine-rich food including cheese, beer or red wine to avoid the occurrence of increased blood pressure or palpitation. 

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.