Zefnart Solution 2% 10 bottles X 10 ml (Trichophyton)

What is Zefnart Solution 2% for tinea (athlete's foot, tinea cruris)?

Zefnart solution with liranaftate is a promising treatment option for tinea infections, including athlete's foot (tinea pedis) and tinea cruris (jock itch). This antifungal medication works through a well-defined mechanism of action, demonstrating its effectiveness in combating these fungal skin infections.

The active ingredient in Zefnart, liranaftate, operates by inhibiting the fungal enzyme squalene epoxidase. This enzyme plays a pivotal role in the biosynthesis of ergosterol, an essential component of fungal cell membranes. By disrupting this process, liranaftate leads to the accumulation of toxic squalene and a subsequent reduction in ergosterol levels. Consequently, fungal cell membranes become weakened and more permeable, leading to cell death and fungal growth inhibition.

Zefnart solution is topically applied to the affected skin areas, allowing for direct contact with the fungal infection site. This targeted approach enhances its effectiveness while minimizing systemic exposure and potential side effects.

Clinical studies have shown that Zefnart solution with liranaftate is highly effective in treating tinea infections. Patients typically experience relief from itching, burning, and scaling within a few days of starting treatment. The recommended treatment duration may vary depending on the severity of the infection.

The unique mechanism of action of liranaftate minimizes the risk of resistance development compared to some other antifungal agents, making it a valuable addition to the treatment armamentarium for tinea infections. Moreover, its topical application ensures ease of use and reduced systemic absorption, contributing to its safety profile.

Active principles: liranaftate 2%

Amount: 10 bottles * 10 ml

Maker: Zenyaku Pharmaceuticals Co., Ltd., Torii Pharmaceutical Co., Ltd., Japan

Indications: treatment of tinea (athlete's foot, tinea cruris)

How to use

Apply this medicine to the affected area once a day. 

Contraindications: do not use for pregnant or breastfeeding women. 

Important information

Do not apply the medicine to eyes (cornea, conjunctiva). If the solution accidentally gets into your eyes, wash it out with water immediately and consult with your doctor.

Do not apply this medicine to the severe erosion.

As this medicine may cause irritation, pay attention when applying it to fissures or eroded surfaces.

This medicine may cause softening of synthetic resin and dissolving of paint. Take care not to touch various surfaces with the solution and not to spill it. 

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.