Vencoll combination tablets for constipation (docusate, dioctyl sulfosuccinate, casanthranol)

What are Vencoll combination tablets for constipation (docusate/dioctyl succinate, casanthranol)?

Vencoll combination tablets contain two key active ingredients: casanthranol and dioctyl sulfosuccinate, also known as docusate. These tablets are specifically designed to address constipation and aid in the elimination of intestinal contents, making them particularly valuable in scenarios like abdominal organ tests and the perioperative period. Furthermore, Vencoll tablets prove to be a effective for patients experiencing constipation as a side effect of opioid medications.

Casanthranol, one of the primary constituents of Vencoll tablets, plays a pivotal role in stimulating bowel movements by directly targeting the myenteric plexus. This network of nerves within the gastrointestinal tract controls the rhythm and coordination of muscle contractions, essential for the smooth progression of fecal matter through the digestive system. Casanthranol's action on the myenteric plexus results in enhanced peristalsis, the wave-like muscular contractions responsible for propelling stool forward in the colon. As a consequence, bowel movements become more regular and efficient.

Docusate, or dioctyl sulfosuccinate, is the second active ingredient in Vencoll tablets and serves a complementary role. It acts by promoting stool softening through two distinct mechanisms. Firstly, docusate increases stool moisture content by absorbing water from the surrounding intestinal environment. This increased hydration of fecal matter helps to make it softer and more pliable, reducing the discomfort and strain often associated with passing hard stools. Secondly, docusate mildly inhibits fluid absorption in the small intestine, allowing water to remain within the stool, further facilitating a smoother and more effortless passage.

By addressing the issue at both ends of the spectrum, with casanthranol promoting peristalsis and docusate softening stool, Vencoll combination tablets provide comprehensive relief to individuals struggling with constipation.

Active principles: dioctyl sodium sulfosuccinate, casanthranol

Amount: 100 tablets

Maker: Nichi-Iko Pharmaceutical Co. Ltd., Toyama, Japan

Indications: treatment of constipation, elimination of intestinal contents during abdominal organ test or perioperative period

How to take

Adults should either take 5-6 tablets at a time, before bedtime, or take 6 tablets a day, dividing into 2-3 doses. This medicine should be taken with a large amount of water.

Your doctor may adjust the dosage according to your age and symptoms.

Contraindications: do not use for the following patients:

• pregnant, possibly pregnant or breastfeeding women,
• patients who are suspected of having acute abdomen,
• patients with severe hard stool,
• patients with spastic constipation.

Important information

Your urine may change color  from yellow-brown to red while taking this medicine. That's completely normal and will return back to yellow after finishing the treatment. 

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.