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TS-1 capsule 20 mg - 56 capsules 20 mg ts1, ts-one, teysuno, tegafur

Product Code:
TSON
Availability:
10
USD 749

What are TS-1 capsules 20 mg for cancer (Teysuno, TS-One)?


TS-1 capsules are a combination medication that incorporates three active components: tegafur, gimeracil, and oteracil potassium. Tegafur serves as a chemotherapeutic prodrug of 5-fluorouracil (5-FU), utilized in cancer treatment. 5-FU mimics pyrimidines, essential components of RNA and DNA, allowing it to integrate into DNA and RNA strands, effectively disrupting the replication process crucial for cancer growth.

Gimeracil plays a vital role in preventing the breakdown of fluorouracil (5-FU), ensuring a sustained and effective concentration against cancer cells. This, in turn, enables the achievement of higher 5-FU concentrations with a reduced tegafur dose, minimizing toxic side effects. Oteracil potassium's function is to diminish the activity of 5-FU in normal gastrointestinal mucosa, thereby mitigating gastrointestinal toxicity.

TS-1 capsules have demonstrated their efficacy in treating a range of cancers, including gastric cancer, colorectal cancer, head and neck cancer, non-small cell lung cancer, inoperable or recurrent breast cancer, pancreatic cancer, biliary tract cancer, and in postoperative adjuvant chemotherapy for hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer cases at high risk of recurrence.


Active principles: 

  • tegafur, 
  • gimeracil, 
  • oteracil potassium

Amount: 56 capsules

Maker: TAIHO Pharmaceutical Co., Ltd., Tokyo, Japan

Indications:

  • gastric cancer,
  • colorectal cancer,
  • head and neck cancer,
  • non-small cell lung cancer,
  • recurrent or unresectable breast cancer,
  • pancreatic cancer,
  • biliary tract cancer.

How to take

The exact dosage and regimen are to be prescribed by your doctor. The general recommendations are the following.

For gastric cancer, colorectal cancer, head and neck cancer, non-small cell lung cancer, inoperable or recurrent breast cancer, pancreatic cancer, biliary tract cancer: adults should take TS-1 twice a day, after breakfast and dinner for 28 consecutive days, followed by 14-day rest. This is counted as one course and is repeated. Initial standard dose of tegafur is determined based on body surface area (BSA) as follows: 40 mg per dose for patients with a BSA less than 1.25 sq.m., 50 mg per dose for patients with a BSA 1.25 to less than 1.5 sq.m., and 60 mg per dose for patients with a BSA equal to or greater than 1.5 sq.m. The dosage may be adjusted according to the patient's condition. Regarding steps of adjustments, dosage is increased or decreased to 40 mg, 50 mg, 60 mg, or 75 mg. The maximum single dose should not exceed 75 mg, and the minimum single dose is 40 mg.

For postoperative adjuvant chemotherapy for HR-positive and HER2-negative breast cancer at high risk of recurrence: in combination with endocrine therapy, adults should take TS-1 twice a day, after breakfast and dinner for 14 consecutive days, followed by 7-day rest. This is counted as one course and is repeated up to 1 year. Initial standard dose of tegafur is determined based on a BSA as follows: 40 mg per dose for patients with a BSA less than 1.25 sq.m., 50 mg per dose for patients with a BSA 1.25 to less than 1.5 sq.m., and 60 mg per dose for patients with a BSA equal to or greater than 1.5 sq.m. The dosage may be adjusted according to the patient's condition. The maximum single dose should not exceed the initial standard dose.

This medicine contains 20 mg of tegafur in each capsule.

Contraindications: do not use for pregnant, possibly pregnant or breastfeeding women. Do not use for patients with bone marrow suppression (low white blood cell count, etc.), kidney disorder, liver disorder, infections, glucose tolerance disorder or stomach and/or small intestine ulcer or bleeding. Do not use for patients with interstitial pneumonia or heart disease or a history of those. If a patient was taking any fluoropyrimidine-group anti-cancer medicines, an appropriate washout period is required before switching to TS-1. 

Important information

TS-1 must not be taken with other fluoropyrimidine-group anti-cancer drugs.

Keep track of your drug intake, your symptoms, and present your records to your pharmacist at your next appointment.

During the treatment, laboratory tests (blood, liver and kidney function tests) should be performed regularly at least once every 2 weeks to detect asymptomatic adverse reactions. 

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.

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