Trerief tablets 50 mg for Parkinson’s disease (zonisamide)

What are Trerief tablets 50 mg for Parkinson's disease (zonisamide)?

Trerief tablets contain zonisamide, a sulfonamide anticonvulsant, and a carbonic anhydrase inhibitor. Initially developed for the treatment of epilepsy, zonisamide has since demonstrated its effectiveness in alleviating symptoms associated with Parkinson's disease. In Japan, Trerief tablets have received approval as an adjunct to levodopa for managing the motor symptoms linked to Parkinson's disease. These tablets offer the following benefits:

• Elevation of dopamine levels.
• Enhancement and prolongation of the antiparkinsonian effects of levodopa.
• Improvement in motor symptoms.
• Mitigation of circadian fluctuations in symptoms, including the wearing-off phenomenon.

Research has revealed that zonisamide achieves these effects by raising dopamine levels, stimulating quinone formation, safeguarding against mitochondrial dysfunction, increasing astroglial cystine transport, inhibiting microglial activation (MAO-B), and blocking calcium channels.

Active principles: zonisamide

Amount: 30 tablets

Maker: Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan

Indications: treatment of Parkinson's disease and parkinsonism in dementia with Lewy bodies

How to take

Adults should take 1 tablet (25 mg of the active principle) once a day, concomitantly with levodopa-containing products. For improvement of circadian change of symptoms in Parkinson's disease, take 2 tablets (50 mg) once a day, concomitantly with levodopa-containing products. 

You can take the medicine with or without water. When taking without water, moisten the tablet with saliva and crush it gently with your tongue. Then, swallow the saliva with the tablet.

Contraindications: do not use for pregnant or breastfeeding women. 

Important information

As this medicine can cause drowsiness and a lack of concentration, avoid driving a car, operating dangerous machinery or working at heights. 

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.