Topina tablets 100 mg for epilepsy (topiramate)

What are Topina tablets 100 mg for epilepsy (topiramate)?

Topina tablets encompass topiramate, which is a modified sulfamate glucose diacetonide. It is sold under the brand names Topamax, Trokendi XR or Qudexy XR.  this medication curbs excessive neural activity in the brain and mitigates partial epileptic seizures. Research indicates that topiramate effectively restrains maximal electroshock and pentylenetetrazol-induced seizures, along with secondarily generalized tonic-clonic seizures in the kindling model.

Topina tablets prove suitable for both children and adults. Notably, topiramate stands apart from other antiepileptic drugs like levetiracetam or carbamazepine by not inducing cell death in juvenile animals. Nonetheless, for optimal efficacy, your healthcare provider might prescribe complementary antiepileptic agents alongside topiramate.

Active principles: topiramate

Amount: 100 tablets

Maker: Kyowa Kirin Co., Ltd., Tokyo, Japan

Indications: treatment of partial seizures in combination with antiepileptic medications

How to take

Adults should start with 50 mg of the active principle (0.5 tablets) at a time, 1-2 times a day. After taking this amount for more than one week the dosage can be gradually increased up to maintenance dose of 1-2 tablets (100-200 mg) at a time, 2 times a day. Your doctor can adjust the dosage according to your symptoms. However, the maximum daily intake of 600 mg should not be exceeded. 

Children of 2 years and older should start with taking 1 mg of the active principle per kilogram of the body weight a day. After taking this amount for more than two weeks, the dose can be increased to 2 mg per kilogram of the body weight a day. After taking this amount for more than two weeks, the dose can be increased by steps of 2 mg per kilogram of the body weight or less up to the maintenance dose of 6 mg per kilogram of the body weight. Your doctor can adjust the dosage according to your symptoms. However, the maximum daily dose should not exceeded 9 mg per kilogram of the body weight or 6 tablets (600 mg), whichever is less. In any case, the daily amount of this medicine should be taken in 2 divided doses.

Contraindications: do not use for the following patients:

• breastfeeding and pregnant women,
• patients with glaucoma,
• patients with hepatic or renal disease,
• patients with depression.

Important information

Patients with calculi should drink enough water and be monitored by a doctor to ensure that the condition is not recurred.

As this medicine can cause sleepiness, patient should avoid driving a car, working at heights or operating dangerous machinery. 

This medicine can cause decrease of sweating and raising of body temperature, especially during hot seasons. To relieve the symptoms, avoid high temperatures and drink plenty of water.

You may lose weight due to the medicine. Talk to your doctor if you notice any unusual weight loss.

Avoid taking any food or supplement containing Hypericum perforatum (St. John's Wort) while taking this medicine. 

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.