Tinidazole tablets 500 mg for Trichomonas vaginalis (nitroimidazole)

What are Tinidazole tablets 500 mg for Trichomonas vaginalis (nitroimidazole)?

Tinidazole is a medication commonly prescribed for the single-dose treatment of Trichomonas vaginalis, an infection that affects the genital and urinary tracts. Its mechanism of action and effectiveness in combating Trichomonas vaginalis are essential aspects to consider in clinical practice.

Tinidazole belongs to the nitroimidazole class of antibiotics, and it exerts its therapeutic effect by disrupting the DNA structure and metabolic processes of the protozoan parasite, Trichomonas vaginalis. Upon administration, Tinidazole is rapidly absorbed and distributed throughout the body. It then undergoes bioactivation by nitroreductase enzymes within the parasite, forming highly reactive compounds. These compounds interfere with the DNA synthesis and repair mechanisms of the parasite, leading to the breakage of DNA strands and ultimately causing cell death.

The single-dose treatment regimen with Tinidazole is advantageous for patient compliance, as it eliminates the need for a prolonged course of therapy. Clinical studies have shown that a single 2 g dose of Tinidazole is highly effective in eradicating Trichomonas vaginalis. Patients are typically instructed to abstain from alcohol during treatment and for at least 72 hours afterward, as the concurrent use of alcohol can lead to a disulfiram-like reaction characterized by severe nausea and vomiting. Effectiveness rates for Tinidazole in treating Trichomonas vaginalis infections are generally high, with cure rates exceeding 90%. 

Active principles: tinidazole 

Amount: 60 tablets

Maker: Fuji Pharma Co., Ltd., Tokyo, Japan

Indications: treatment of  Trichomonas vaginalis

How to take

Adults should take 4 tablets (2000 mg of the active principle) as single-dose treatment. If the test shows the remaining infection after treatment, it should be repeated with an interval of at least 1 week from the first intake. 

Contraindications: do not use for pregnant women within first 3 months of pregnancy, possibly pregnant or breastfeeding women. 

Important information

Do not take alcohol during the treatment and for at least 3 days after finishing the treatment, as the combination of the active principle with alcohol may cause strong adverse reaction. 

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.