Tienam ampoules for IV 0.5 g (Primaxin, Imipenem/Cilastatin)
What are Tienam ampoules IV 0.5 g (Primaxin, Imipenem, Cilastatin)?
Tienam ampoules, composed of imipenem hydrate and cilastatin sodium, exhibit their therapeutic effects through a specific mechanism of action. Imipenem hydrate is a potent antibiotic that belongs to the carbapenem class. It functions by inhibiting the synthesis of bacterial cell walls, thereby disrupting their structural integrity. This leads to bacterial cell death as a result of osmotic instability. Imipenem's broad-spectrum activity enables it to effectively combat a wide range of gram-positive and gram-negative bacteria, making it useful in treating various infections.
Cilastatin sodium, on the other hand, serves a different purpose. It is administered alongside imipenem to prevent the degradation of imipenem by renal dehydropeptidase enzymes in the kidneys. This combination helps to maintain adequate levels of imipenem in the bloodstream and enhances its therapeutic effectiveness.
The synergistic action of imipenem hydrate and cilastatin sodium in Tienam ampoules contributes to their clinical efficacy in treating severe bacterial infections.
Active principles: imipenem hydrate, cilastatin sodium
Amount: 10 vials
Maker: Nippon Chemiphar Co. Ltd., Tokyo, Japan
Indications: broad range of bacterial infections, including following:
- lower respiratory tract infections,
- urinary tract infections,
- gynecologic infections,
- bone and joint infections,
- secondary infection of trauma,
- infectious endocarditis,
- liver abscess,
- bacterial sepsis.
How to use
Dissolve 0.5 g of this drug with 100mL of physiological saline and shake well to dissolve. Do not use water for injection as the solution does not become isotonic. Since this drug is chemically unstable with lactate, it does not dissolve in solutions containing lactate.
For adults, 0.5-1.0 g of imipenem per day should be divided into 2-3 times and injected intravenously over 30 minutes.
For children, 30-80 mg of imipenem/kg of weight per day should be divided into 3-4 times and injected intravenously over 30 minutes.
The doctor in charge may adjust the dosage according to the patient's age, disease and symptoms. For severe/refractory infections, the dosage may be increased up to 2 g per day for adults, and up to 100 mg/kg of weight per day for children.
Contraindications: do not use for pregnant or breastfeeding women. Do not use for patients taking sodium valproate. Use with caution for elderly patients, patients with liver or renal impairment, bronchial asthma, hives, central nervous system disorders, epilepsy, rash, parenteral nutrition or poor oral intake.
If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.