What are Sigmart tablets 5 mg for angina (nicorandil)?
Sigmart tablets are formulated with the active ingredient nicorandil, an ester of nicotinamide known for its dual mechanism of action as both a nitrate and an ATP-sensitive K+ channel agonist. This medication is available under various brand names across different countries, such as Ikorel, Angedil, Dancor, Nikoran, Nitorubin, and others, catering to a wide range of markets.
Nicorandil, found in Japanese Sigmart tablets, operates through a multifaceted approach. By acting as a nitrate, it encourages vasodilation by releasing nitric oxide, a molecule that dilates blood vessels. This dilation, in turn, eases the strain on the cardiovascular system and leads to increased blood flow. Furthermore, the ATP-sensitive K+ channel agonist property of nicorandil contributes to its vasodilatory effect. This mechanism involves the opening of potassium channels in vascular smooth muscle cells, leading to hyperpolarization, relaxation of smooth muscle, and ultimately, the relaxation of blood vessels.
Specifically, Sigmart tablets exhibit their primary therapeutic action in the context of coronary vasodilation. These tablets, designed for oral administration, efficiently reduce the calcium sensitivity of smooth muscle cells. This action holds a pivotal role in the relaxation of the smooth muscles within coronary arteries, leading to their dilation. This dilation occurs not only in normal coronary arteries but also in those constricted due to stenosis or spasm. Thus, Sigmart tablets demonstrate their effectiveness in enhancing blood flow through the coronary arteries.
The clinical application of Sigmart tablets has been extensively studied and demonstrated their efficacy in addressing various cardiovascular conditions. Particularly, these tablets hold promise in alleviating symptoms associated with chest pain and the sensation of chest oppression that arise due to compromised blood flow to the heart. Patients afflicted with angina, spanning from mild to severe forms including vasospastic angina, have found relief with the administration of Sigmart tablets.
In addition to symptom management, studies have unveiled a notable cardioprotective aspect of Sigmart tablets. When incorporated into an intervention strategy immediately following an acute myocardial infarction (heart attack) in high-risk patients, these tablets showcased a positive impact. This suggests that their mechanisms of action contribute to the reduction of further cardiac damage and improvement of overall cardiac function during the critical post-heart attack period.
Active principles: nicorandil
Amount: 100 tablets
Maker: Chugai Pharmaceutical Co., Ltd., Tokyo, Japan
Indications: treatment of angina and such its symptoms as chest pain and chest oppressive feeling.
How to take
Adults should take 1 tablet at a time, 3 times a day.
The dosage may be adjusted by your doctor according to age, body weight and symptoms.
Contraindications: do not use for the following patients:
- patients with hepatic disorder,
- patients with glaucoma,
- pregnant women,
- breastfeeding women.
Never take sildenafil citrate (Viagra), vardenafil hydrochloride hydrate (Levitra) or tadalafil (Cialis) while taking this medication.
If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.