Samtirel oral suspension 15% for pneumocystis pneumonia (atovaquone)

What is Samtirel oral suspension 15% for pneumocystis pneumonia (atovaquone)?

Samtirel oral suspension with atovaquone is a medication used in the treatment of Pneumocystis pneumonia, an opportunistic fungal infection primarily affecting individuals with compromised immune systems. This medication functions by employing a mechanism of action that targets the proliferation of the fungi responsible for causing Pneumocystis pneumonia, specifically Pneumocystis jiroveci.

The primary mode of action of Samtirel is to disrupt the electron transport chain in the mitochondria of Pneumocystis jiroveci. This inhibition leads to a reduction in ATP production, which is crucial for the energy needs of the fungi. Consequently, the compromised energy metabolism impairs the growth and replication of the pathogen, ultimately reducing its ability to cause infection and improving the patient's symptoms.

The effectiveness of Samtirel in treating Pneumocystis pneumonia is well-established through clinical trials and medical practice. It has shown notable efficacy in suppressing the proliferation of Pneumocystis jiroveci, leading to symptom improvement and preventing symptom onset. 

Active principles: atovaquone

Amount: 14 sachets * 5 ml

Maker: GlaxoSmithKline K.K., Tokyo, Japan

Indications: treatment of pneumocystis pneumonia and suppressing the symptom onset.

How to take

For the treatment of pneumocystis pneumonia: adults should take 1 sachet (5 ml of suspension, 750 mg of the active principle) at a time, 2 times a day, after meals for 21 days.

For suppressing symptom onset of pneumocystis pneumonia: adults should take 2 sachets (10 ml, 1,500 mg of the active principle) at a time, once a day, after a meal.

Contraindications: do not use for pregnant or breastfeeding women. 

Important information

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.