Rilmazafone hydrochloride tablets 2 mg for insomnia (RHYTHMY)

What are Rilmazafone hydrochloride tablets 2 mg (RHYTHMY) for insomnia?

Rilmazafone hydrochloride, a water-soluble prodrug of benzodiazepine, was developed by Japanese researchers. This unique compound holds the ability to enhance the effects of the inhibitory neurotransmitter GABA within the central nervous system. By intensifying GABA's function, rilmazafone demonstrates a capacity to alleviate anxiety, dissipate tension, and act as a potent sleep inducer.

The mechanism of action behind rilmazafone's anxiolytic and sedative effects is quite intricate. As a prodrug, it undergoes a specific metabolic transformation in the body, leading to the liberation of its active form. Once metabolized, rilmazafone interfaces with GABA receptors in the brain, augmenting the receptor's affinity for GABA molecules. This heightened interaction between the prodrug and GABA receptors results in increased receptor activation and an amplified influx of chloride ions into neurons. Consequently, this hyperpolarization of the neuron membrane impedes excitatory signals, rendering the central nervous system more receptive to the calming influence of GABA. The net effect is a profound sense of tranquility, alleviation of anxiety, and the induction of restful sleep patterns.

Clinical studies have confirmed the efficacy of rilmazafone in managing anxiety disorders and sleep disturbances. The drug's ability to enhance GABAergic transmission effectively addresses the root causes of these conditions, making it a preferred choice in therapeutic regimens. Moreover, rilmazafone's water-soluble nature contributes to its rapid onset of action.

One of the most remarkable aspects of rilmazafone is its exceptional safety profile. Unlike traditional benzodiazepines, which often carry the risk of undesirable side effects, rilmazafone is remarkably well-tolerated. This attribute makes it particularly suitable for elderly patients, who are more vulnerable to adverse reactions. Moreover, its selectivity for GABA receptors minimizes the likelihood of respiratory depression, which is a significant concern associated with some other sedative medications. The drug's unique pharmacokinetic properties ensure that it does not induce lingering next-day residual effects.

Active principles: rilmazafone hydrochloride

Amount: 100 tablets

Maker: Kyowa Pharmaceutical Industry Co., Ltd., Osaka, Japan

Indications: treatment of insomnia; as a pre-anesthetic medication

How to take

For insomnia treatment: adults should take 0.5-1 tablet once a day before going to bed.

For pre-anesthetic effects: adults should take 1 tablet once a day, before going to bed or prior to surgery.

Your doctor may adjust the dosage based on age, weight, and symptoms.

Contraindications: do not use for the following patients:

• breastfeeding or pregnant women,
• patients with myasthenia gravis or glaucoma,
• patients with diseases of the lungs or respiratory system,
• patients with severe disabilities,
• patients with a heart, liver, renal, or brain disorder.

Important information

As this medicine may cause sleepiness, patient should avoid driving a car, working at high altitudes, or operating any dangerous machinery. 

Avoid drinking alcohol and taking caffeine (tea, coffee) during treatment as it may intensify the adverse reactions. 

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.