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Progynon Depot (estrogen, hormonal imbalance, menopause, Estradiol Valerate)

Product Code:
USD 100

What are Progynon Depot injections (estradiol valerate)?

Hormonal imbalances during menopause causes various unpleasant symptoms, including persistent sweating, heart palpitations, vaginal mucosa atrophy leading to itching, burning, and discomfort, anxiety, memory impairment, and an increased risk of osteoporosis, among others. 

Estradiol is the most potent female sex hormone, popular for the hormone replacement therapy. Progynon Depot injections provide the optimal dosage of estradiol in each ampoule (10 mg), which is carefully calibrated to compensate for the deficiency of natural hormones. This medicine features prolonged duration of action within the body, ensuring sustained effects, making it one of the most popular choices for alleviating symptoms of menopause in Japan. 

Progynon Depot injections are also used for the following purposes:

Prevention of osteoporosis in postmenopausal women. By bolstering bone density, Progynon Depot serves as a preventive measure against the debilitating effects of osteoporosis commonly encountered after menopause.

Hormonal therapy for transsexual operations (male to female): Progynon Depot plays a crucial role in assisting individuals undergoing male-to-female transition by facilitating the development of feminine characteristics through hormonal manipulation.

Treatment of amenorrhea in young women: Progynon Depot is employed in the management of amenorrhea, a condition characterized by the absence of menstruation, to restore regular menstrual cycles and promote hormonal equilibrium in young women.

Symptomatic treatment of androgen-dependent prostate cancer: In the context of androgen-dependent prostate cancer, Progynon Depot is employed to alleviate the symptoms associated with the disease, providing relief and improving the quality of life for affected individuals.

Active principles: estradiol valerate

Amount: 10 vials * 10 mg

Maker: Fuji Pharma Co., Ltd., Tokyo, Japan


  • treatment of hormonal imbalance during menopause,
  • prevention of osteoporosis for women after menopause,
  • hormonal therapy for transsexual operations (male to female),
  • treatment of amenorrhea for young women,
  • treatment of the symptoms of androgen-dependent prostate cancer,
  • treatment of mammary carcinoma. 

How to use 

The medicine should be injected intramuscularly. The regimen and duration of the treatment should be prescribed by your doctor. 

Contraindications: do not use for pregnant and breastfeeding women. Do not use for patients with liver diseases. Due to high hormonal activity this medicine is not recommended for women with a history of tumors of mammary glands and reproductive organs. Not recommended for very young patients, because while the growth hormone is still produced in the body, hormonal therapy won't be sufficient. As estradiol reduces the effectiveness of insulin and other sugar reducing drugs, patients with diabetes should consult with their doctor before use.

Important information

Such effects such as increased breast size, accelerated fat metabolism and increased libido may occur. 

Estradiol is not associated with increase cancer risk.

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.

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