Pirfenidone is a synthetic pyridone derivative and an antifibrotic oral agent. It works by reducing fibroblast proliferation, inhibiting transforming growth factor beta stimulated collagen production, reducing the production of fibrogenic mediators and reducing production of inflammatory mediators. As the result, Pirfenidone tablets inhibit fibrosis in lung and suppress the aggravation of pulmonary function.
Pirfenidone tablets are effective for the treatment of idiopathic pulmonary fibrosis. Researches showed that treatment with pirfenidone helps to decrease the rate of decline in vital capacity and to increase the progression-free survival time over 52 weeks.
Active principles: pirfenidone
Amount: 100 tablets
Maker: Nichi-Iko Pharmaceuticals Co., Ltd., Toyama, Japan
Indications: idiopathic pulmonary fibrosis
Adults should start with 1 tablet (200 mg of active principle) at a time, 3 times a day, after meals, as the initial dosage. Then gradually increase the dose by the steps of 1 tablet (200 mg) at a time, with the intervals of at least 2 weeks between the steps. The maintenance dose is 3 tablets (600 mg) at a time, 3 times a day. Your doctor should closely monitor the symptoms and the response and adjust the dosage if needed.
Contraindications: do not use for pregnant, possibly pregnant or breastfeeding women.
If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.
