Pirfenidone tablets 200 mg for idiopathic pulmonary fibrosis (Esbriet, Pirespa, Etuary)

What are Pirfenidone tablets 200 mg for idiopathic pulmonary fibrosis (Esbriet, Pirespa, Etuary)?

Pirfenidone is a synthetic pyridone derivative and an antifibrotic oral agent. It works by reducing fibroblast proliferation, inhibiting transforming growth factor beta stimulated collagen production, reducing the production of fibrogenic mediators and reducing production of inflammatory mediators. As the result, Pirfenidone tablets inhibit fibrosis in lung and suppress the aggravation of pulmonary function.

Pirfenidone tablets are effective for the treatment of idiopathic pulmonary fibrosis. Researches showed that treatment with pirfenidone helps to decrease the rate of decline in vital capacity and to increase the progression-free survival time over 52 weeks.

Active principles: pirfenidone

Amount: 100 tablets

Maker: Nichi-Iko Pharmaceuticals Co., Ltd., Toyama, Japan

Indications: idiopathic pulmonary fibrosis

How to take

Adults should start with 1 tablet (200 mg of active principle) at a time, 3 times a day, after meals, as the initial dosage. Then gradually increase the dose by the steps of 1 tablet (200 mg) at a time, with the intervals of at least 2 weeks between the steps. The maintenance dose is 3 tablets (600 mg) at a time, 3 times a day. Your doctor should closely monitor the symptoms and the response and adjust the dosage if needed.

Contraindications: do not use for pregnant, possibly pregnant or breastfeeding women.

Important information

• Avoid taking this medicine on the empty stomach..
• To prevent the occurrence of photosensitivity, a patient should use an adequate ultraviolet protection: wearing adequate clothes (including hat, scarf, etc.); using a parasol and a sunscreen with high protective properties (SPF50+, PA+++).
• As this medicine may cause sleepiness or dizziness, patients should avoid driving a car, operating dangerous machinery or working at heights.
• Patient should avoid smoking while taking the medicine as it may weaken the effectiveness. 

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.