Onetram tablets 100 mg for cancer and chronic pain (tramadol hydrochloride, Ultram, Tramal)

What are Onetram tablets 100 mg for cancer and chronic pain (tramadol hydrochloride, Ultram, Tramal)?

An active principle of Onetram tablets is tramadol hydrochloride, a strong opioid pain medication. It works by binding to opioid receptor and inhibiting reuptake of monoamine. With a 60-year history of use, tramadol remains one of the most commonly prescribed medication in many countries all over the world. 

Onetram tablets are manufactured via a new patented technology by Endo and Pfizer, with a dual structure of the peripheral part with immediate release and the central part with sustained release. This structure makes the effect of this medicine both rapid and durable.

Onetram tablets are effective for relieving severe pain, including cancer pain, postoperative pain and chronic pain that is non-responsive to non-opioid analgesics. Studies showed that sustained release formulation allows tramadol to achieve stable serum levels without marked peak to trough fluctuations and reduced frequency of dosing.

Active principles: tramadol hydrochloride

Amount: 100 tablets

Maker: Nippon Shinyaku Co., Ltd., Kyoto, Japan

Indications: relieving severe pain, including cancer pain, postoperative pain and chronic pain that is non-responsive to non-opioid analgesics.

How to take

Adults should take 1-3 tablets (100 to 300 mg of the active principle) at a time, once a day. The doctor in charge may adjust the dosage according to the disease, age or symptoms. But the maximum dose of 400 mg a day should not be exceeded. For elderly people over 75 years old, the daily dose is usually up to 300 mg.

The tablet should be swallowed without splitting, crushing or chewing.

Contraindications: do not use for the following categories of patients:

• patients with acute intoxication caused by alcohol,
• patients taking sleeping pills, painkillers, opioid pain relievers or psychotropic drugs,
• patients with epilepsy or head injury with inadequate therapeutic management,
• patients who have used other drugs like monoamine oxidase inhibitor, drinking acid salt (Azilect), saffinamide mesylate (Ekfina) or nalmefene hydrochloride hydrate within the past 2 weeks,
• children under 12 years old
• patients under the age of 18 with obesity, obstructive sleep apnea syndrome or severe lung disease,
• patients with renal disorder or liver disorder,
• pregnant or breastfeeding women.

Important information

This medicine can not be used as a rescue dose, in case of sudden cancer pain exacerbation. If the patient needs a rescue dose, they should take a preparation of tramadol hydrochloride with immediate release.

As this medicine may cause dizziness or sleepiness, patient should avoid operating dangerous machinery, working at heights or driving a car while taking this medicine.

Avoid drinking alcohol while taking this medicine as it may intensify medical effects and adverse reactions.

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.