Marizev 25 mg (diabetes) 20 tablets for 20 weeks

What are Marizev tablets 25 mg for diabetes?

Marizev tablets are a revolutionary Japanese medication for the treatment of diabetes. Their active principle is omarigliprin, an inhibitor of the enzyme degrading hormone called DPP-4. It helps to stimulate the insulin secretion when blood sugar rises and thus to improve the blood glucose control. Taking only 1 tablet a week together with sufficient diet allows to avoid taking insulin injections. 

Omarigliptin was officially approved for the treatment of type II diabetes in Japan in 2015. First manufactured by MSD (Merck & Co., Inc.), since 2020 the rights for manufacturing and marketing omarigliptin in Japan were transferred to Kissei Pharmaceutical. Marizev tablets provide the following effects: 

• lower blood sugar,
• reduce sugar absorption during meals,
• stabilize blood glucose level,
• normalize the renal function.

Active principles: omarigliptin

Amount: 20 tablets for 20 weeks

Maker: Kissei Pharmaceutical Co., Ltd., Matsumoto, Nagano, Japan

Indications: diabetes mellitus II type

How to take

Adults should take 1 tablet (25 mg of active principle) at a time, once a week, always on the same day of the week. 

Patients with severe or end stage renal dysfunction should take 12.5 mg of the active principle at a time, once a week, always on the same day of the week. This medicine contains 25 mg of omarigliptin in 1 tablet. 

Contraindications: do not use for the following patients:

• patients with type I diabetes,
• patients with ketosis, in diabetic coma or precoma stage, 
• patients with infection requiring glycemic control by insulin injection, 
• patients with injury, 
• patients with renal dysfunction, 
• patients with pituitary or adrenal gland disorder, 
• people with insufficient diet,
• patients in pre/postoperative period or debilitated,
• people who exercise intensely or drink a lot of alcohol,
• pregnant or breastfeeding women. 

Important information

As hypoglycemic symptoms may occur, patient should pay attention when working at heights, driving a car or operating dangerous machinery. In case of hypoglycemic symptoms patient should take food or drink that contains enough amount of sugar (sugar, glucose, etc.). If the patient is taking the medicine concomitantly with an alpha-glucosidase inhibitor, they should take glucose in case of any hypoglycemic symptoms.

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.