Linzess tablets 0.25 mg for constipation (Constella)

What are Linzess tablets 0.25 mg for constipation (linaclotide, Constella)?

An active principle of Linzess tablets is linaclotide, a synthetic tetradecapeptide that mimics endogenous guanylin or uroguanylin. It works by affecting the guanylate-cyclase C receptor at the surface of intestinal epithelium. Linzess tablets increase water secretion, affect colonic sensory neurons and decrease abdominal pain. By activating colonic motor neurons, this medicine promotes smoother muscle contraction and eases defecation.

Linzess tablets are effective for the treatment of chronic constipation of various genesis and irritated intestinal syndrome. Linaclotide is a safe, effective and well-tolerated medication.

Active principles: linaclotide

Amount: 100 tablets

Maker: Astellas Pharma Inc., Tokyo, Japan

Indications:

• chronic constipation,
• hypersensitivity in large intestine,
• mild abdominal pain,
• discomfort in abdominal area,
• constipation-predominant irritable bowel syndrome.

How to take

Adults should take 2 tablets (0.5 mg of active principle) at a time, once a day, before meal. Depending on the severity of symptoms, your doctor may reduce the dosage to 1 tablet.

Contraindications: do not use for pregnant or breastfeeding women. Do not use for patients with  mechanical intestinal obstruction, or suspection of it.

Important information

These tablets are highly hygroscopic, so they need to be removed from the sheet directly before use. Do not leave the tablets unwrapped or move them to another container. 

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.