An active principle of Kalgut tablets is denopamine, a beta-1 adrenergic receptor antagonist acting as a cardiotonic. It provides the following effects:
The main indication of Kalgut tablets is treatment of chronic heart failure and angina pectoris. As denopamine is highly selective, it is effective even for patients who failed the treatment with other beta-1 receptor agonists such as prazosin and nicorandil. Denopamine does not affect the phosphodiesterase, provides inotropic effects with minimal formation of cyclic AMP or stimulation of adenylate cyclease. In other words, denopamine has a lower risk of desensitizing beta-1 adrenergic nerve receptors than other medications of its class. That's why Kalgut tablets are often prescribed in Japan for the long-term treatment of chronic heart failure.
Active principles: denopamine
Amount: 100 tablets
Maker: Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
Indications: treatment of chronic heart failure
Adults should take 5-10 mg of active principle 3 times a day. Your doctor can adjust the dosage according to your age and symptoms. In case these tablets are prescribed for your for other purposes than chronic heart failure (digitalis diuretic, vasodilator, etc.), the dosage and the frequency should be prescribed by your doctor.
These tablets contain 10 mg of active principle in 1 tablet.
Contraindications: do not use for pregnant or breastfeeding women.
If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.
