What are Januvia tablets 100 mg for type 2 diabetes?
The active principle of Januvia tablets is sitagliptin, an inhibitor of enzyme called dipeptidyl peptidase 4(DPP-4). This enzyme destroys hormones that stabilize blood glucose levels after meals. Sitagliptin stops enzyme degrading, increases insulin production and normalizes blood glucose levels.
Januvia tablets also prevent hypoglycemia by temporarily suppressing the hormone glucagon and increasing insulin production. When glucose levels reach normal, the suppression stops and blood glucose levels drop. Januvia tablets do not increase weight or aren't associated with any of major adverse cardiovascular events. Japanese doctor particularly often prescribe sitagliptin for for patients who are overweight or 65+. This medicine is well-tolerated, safe and can be combined with other medications. Due to prolonged effect, taking sitagliptin orally only once a day is enough.
Active principles: sitagliptin phosphate hydrate
Amount: 100 tablets
Maker: MSD K.K., Tokyo, Japan
Indications: lowering blood glucose levels in patients with type 2 diabetes
How to take
For patients with normal renal function or mild dysfunction: take 50 mg of active principle once a day. Your doctor can adjust the dosage to 1 tablet (100 mg) once a day if the effect is insufficient.
For patients with moderate renal dysfunction: take 25 mg of active principle once a day. Your doctor can adjust the dosage to 50 mg once a day if the effect is insufficient.
For patients suffering from severe or end-stage renal dysfunction: take 12.5 mg of active principle once a day. Consult your doctor if the dosage is not sufficient.
Please note, 1 tablet contains 100 mg of sitagliptin as active principle.
Contraindications: do not use for the following patients:
- Patients with type 1 diabetes,
- Patients in precoma or diabetic coma,
- Patients with ketosis,
- Patients with injuries or infections,
- Patients in the preoperative and postoperative period, or who are debilitated,
- Patients with adrenal gland or pituitary disorder,
- Patients who consume excessive alcohol or eat insufficiently,
- Patients with a history of abdominal surgery, or intestinal obstruction,
- Patients who exercise intensely,
- Breastfeeding or pregnant women,
If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.