Jadenu granules sachet 360 mg for chronic iron overload (Deferasirox, Exjade, Asunra, Oleptiss)

What are Jadenu granules sachet 360 mg for chronic iron overload (Deferasirox, Exjade, Asunra, Oleptiss)?

An active principle of Jadenu granules is deferasirox, an oral iron chelator. It works by binding and excreting excessively accumulated iron from the body. Deferasirox removes the excessive iron not only from the blood, but also from the cells, such as cardiac myocytes and hepatocytes.

Jadenu granules are effective for the treatment of chronic iron overload due to blood transfusions for conditions such as beta-thalassemia and other chronic anemias. This medicine is particularly recommended for use in case the treatment with iron chelator injection is inadequate. Due to low molecular weight and high lipophilicity of deferasirox, it can be taken orally unlike other chelators like deferoxamine.

Active principles: deferasirox

Amount: 30 sachets

Maker: Novartis Pharma K.K., Tokyo, Japan

Indications: treatment of chronic iron overload due to blood transfusions

How to take

Take 12 mg of the active ingredient per kg of body weight at a time, once a day. Your doctor can adjust the dosage according to your symptoms. However, the maximum dosage of 18 mg/kg per day should not be exceeded.

Please note that 1 sachet of this medicines contains 360 mg of the active ingredient. 

Contraindications: do not use for the following categories of patients:

• Patients with blood platelet count less than 50,000/mm3,
• Patients with myelodysplastic syndrome,
• Patients with malignancy,
• Pregnant or breastfeeding women,
• Patients with renal or liver disorder.

Important information

As this medicine may cause dizziness, visual or hearing impairment, patients should take care when driving a car or operating dangerous machinery after administering this medicine.

If this medicine is taken together with 500 mg or more vitamin C orally, the combination may cause the deterioration of cardiac function. Patients should consult with their doctor or pharmacist when taking any medicines or supplements including vitamin C.

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.