Excegran tablets for epilepsy seizures from Japan

What are Excegran (zonisamide) tablets 100 mg for epilepsy seizures?

The active principle of Excegran tablets is zonisamide, a sulfonamide unrelated to any other antiseizure agent. It works by blocking sodium and T-type calcium channels and, by this, suppressing neuronal hypersynchronization. Also, zonisamide modulates GABAergic and glutamatergic neurotransmission. As the result, Excegran tablets are effective for both adjunctive and monotherapy for patients with epilepsy, including partial seizures (simple, complex, secondarily generalized), generalized (tonic, tonic-clonic (grand mal), and atypical absence) and combined seizures.

Active principles: zonisamide

Amount: 100 tablets

Maker: Sumitomo Dainippon Pharma, Osaka, Japan

Indications:

• Temporal lobe epilepsy,
• Focal disturbances of consciousness (complex partial seizures),
• Refractory seizures
• Secondarily generalised seizures (bilateral tonic-clonic seizures)
• Focal disturbances of consciousness (simple partial seizures).

How to take

Adults: on the first day, take 100 to 200mg of the active principle in 1 to 3 divided doses. Then, increase the dose gradually, with a step of every 1 to 2 weeks, to 200 to 400mg a day in 1 to 3 divided doses.

Children: on the first day, take 2 to 4mg of the active principle per 1 kg of weight in 1 to 3 divided doses. Then, increase the dose gradually, with a step of every 1 to 2 weeks, to 4 to 8 mg per kg of weight in 1 to 3 divided doses a day.

The maximum dose is 600 mg of the active principle a day for adults, 12mg/kg of the active principle a day for children. 

Contraindications: do not use for pregnant or breastfeeding women. 

Important information

These tablets may cause sleepiness, lack of attention and concentration. Do not drive a car, work at heights or operate dangerous machinery while taking this medicine. 

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.