Corectim ointment 0.5% for atopic dermatitis (delgocitinib)

What is Corectim ointment 0.5% for atopic dermatitis?​

Corectim ointment, containing the active ingredient delgocitinib, is a topical medication used in the management of atopic dermatitis. Its mechanism of action primarily revolves around the inhibition of Janus kinases (JAKs), specifically JAK1 and JAK3. These enzymes play a pivotal role in the signal transduction pathway of various cytokines and growth factors involved in immune and inflammatory responses.

Delgocitinib exerts its effect by competitively binding to these JAK enzymes, thereby disrupting their signaling cascade. This interference results in the downregulation of cytokines such as interleukins (IL-2, IL-4, IL-13, etc.) and interferon-gamma (IFN-γ), which are known to drive inflammatory processes and immune responses associated with atopic dermatitis. By inhibiting the JAK-STAT pathway, Corectim ointment effectively dampens the immune and inflammatory reactions, leading to a reduction in the severity of symptoms seen in atopic dermatitis.

Clinical trials have demonstrated the effectiveness of Corectim ointment in managing atopic dermatitis by reducing pruritus, erythema, and skin lesions. 

Active principles: delgocitinib

Amount: 10 tubes * 5 g

Maker: Torii Pharmaceutical Co., Ltd., Tokyo, Japan

Indications: treatment of atopic dermatitis

How to use

For adults: apply a small amount of this medicine to the affected area 2 times a day. A single dose should not exceed 5 g at a time. 

For children: apply a small amount of 0.25% formulation to the affected area 2 times a day. Depending on symptoms, your pediatrician may prescribe applying this medicine (0.5% formulation) to the affected area 2 times a day. The applied dose should not exceed 5 g at a time. When the symptoms improve,  this medicine may be replaced with a 0.25% formulation.

Contraindications: do not use for pregnant or breastfeeding women. 

Important information

• If the symptoms do not improve after 4 weeks of treatment with this medicine, consult with your doctor.
• Do not apply to area affected by skin infection.
• Do not apply to mucosa, injured skin or eroded area.
• If this medicine gets into your eyes, wash out with water immediately.

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.