Clarithromycin tablets 200 mg for Helicobacter pylori eradication

What are Clarithromycin tablets 200 mg for Helicobacter pylori eradication? 

Clarithromycin is a macrolide antibiotic that is commonly employed in the management of various conditions associated with Helicobacter pylori (H. pylori) infection. Its mechanism of action primarily revolves around inhibiting bacterial protein synthesis. Clarithromycin binds to the 50S ribosomal subunit of the H. pylori bacterium, thereby disrupting the formation of peptide bonds and preventing the growth and replication of the organism.

For patients with gastric ulcers and duodenal ulcers, Clarithromycin is often incorporated into a combination therapy, which includes proton pump inhibitors and other antibiotics. This regimen serves to effectively eradicate H. pylori and reduce the risk of ulcer recurrence. In the context of gastric MALT (Mucosa-Associated Lymphoid Tissue) lymphoma, the antibiotic has been utilized as part of a first-line treatment strategy, aiming to achieve regression of the lymphoma by eradicating the causative H. pylori infection.

In idiopathic thrombocytopenic purpura (ITP), Clarithromycin may help by modulating the immune response and potentially increasing platelet counts. After endoscopic treatment for early-stage gastric cancer, Clarithromycin plays a role in preventing H. pylori-associated recurrences and complications. By eradicating the bacterium, it reduces the risk of metachronous cancer development.

In the case of H. pylori-associated gastritis, Clarithromycin-containing regimens are utilized to reduce inflammation and prevent disease progression. These regimens are considered effective in achieving H. pylori eradication, which, in turn, helps in improving the chronic gastritis and reducing the risk of developing more severe gastric conditions.

Active principles: clarithromycin

Amount: 100 tablets

Maker: Sawai Pharmaceutical Co. Ltd., Osaka, Japan

Indications: eradication of Helicobacter pylori infection in following:

gastric ulcer, 

duodenal ulcer, 

gastric MALT lymphoma, 

idiopathic thrombocytopenic purpura, 

after endoscopic treatment for early-stage gastric cancer, 

Helicobacter pylori-associated gastritis.

How to take

Adults should take 1 tablet (200 mg) at a time, concomitantly with 750 mg of amoxicillin hydrate and proton pump inhibitor (such as: 30 mg of lansoprazole at a time, 20 mg of omeprazole at a time, 10 mg of rabeprazole sodium at a time, 20 mg of esomeprazole at a time or 20 mg of vonoprazan at a time), 2 times a day a day for 7 days. Your doctor may increase the dosage according to your symptoms. However, the maximum daily dose is 2 tablets (400 mg) at a time, 2 times a day.

Contraindications: do not use for patients with liver or renal dysfunction. Do not use for pregnant or breastfeeding women. 

Important information

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.