Cholebine tablets 500 mg for hypercholesterolemia and familial hypercholesterolemia (colestimide, colestilan, BindRen)

What are Cholebine tablets 500 mg for hypercholesterolemia and familial hypercholesterolemia (colestimide, colestilan, BindRen)?

Cholebine tablets, which contain the active ingredient colestimide, are commonly prescribed for the management of hypercholesterolemia and familial hypercholesterolemia. This medication functions by leveraging its bile acid-binding properties to reduce serum cholesterol levels effectively.

The mechanism of action of Cholebine tablets primarily revolves around their ability to adsorb bile acids and cholesterol in the digestive tract. Colestimide acts as a bile acid sequestrant, working by binding to bile acids in the intestinal lumen. By forming non-absorbable complexes with bile acids, Cholebine inhibits their reabsorption and promotes their elimination via feces. This prompts the liver to enhance the utilization of cholesterol to synthesize new bile acids, thereby reducing the overall cholesterol content in the bloodstream.

Cholebine's effectiveness in lowering cholesterol levels is well-documented. By intercepting bile acids, it disrupts the enterohepatic circulation of these acids, forcing the liver to draw upon cholesterol reserves to synthesize more bile acids. Consequently, this depletes the cholesterol pool within the liver and results in the upregulation of low-density lipoprotein (LDL) receptors on hepatocytes. This increased expression of LDL receptors on liver cells further contributes to the removal of LDL cholesterol from the blood.

In the context of familial hypercholesterolemia, a genetic disorder characterized by high levels of LDL cholesterol, Cholebine tablets offer a non-systemic approach to re, making it a valuable adjunct to other lipid-lowering therapies. Cholebine tablets may also be used in combination with other medications.

Active principles: colestimide

Amount: 100 tablets

Maker: Mitsubishi Tanabe Pharma Corporation, Osaka, Japan

Indications: treatment of hypercholesterolemia and familial hypercholesterolemia

How to take

Adults should take 3 tablets (1.5 g of the active principle) at a time, 2 times a day, before breakfast and dinner. Your doctor may also prescribe to take this medicine after breakfast and dinner depending on your symptoms or dosing condition. Your doctor may adjust the dosage according to your disease, age and symptoms. However, the maximum daily dose of 8 tablets (4 g) should not be exceeded. 

Contraindications: do not use for pregnant or breastfeeding women, for patients with complete biliary obstruction or intestinal obstruction. 

Important information

Try to swallow this medicine as promptly as possible. If you couldn't promptly swallow the tablet and it remained in your mouth or back of the throat, drink more water.

Don't take this medicine with warm water, use water of a room temperature or cold water. 

If an allergic reaction occurs, patient needs to stop using the medicine and consult with their doctor. If patient is taking any other medication or treatment, they should consult with their doctor in advance.